Saccharomyces cerevisiae (S288c)

ADE1

phosphoribosylaminoimidazolesuccinocarboxamide synthase, L000000031, YAR015W

N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress

GO Process (2)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

'de novo' IMP biosynthetic process [IDA, IMP]

purine nucleotide biosynthetic process [IDA, IMP]

Gene Ontology Molecular Function

phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [IDA, IMP]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleus [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

31799

559292

PTM statistics

Proteins

PTM Sites

Publications

Sumoylation Sites (1)
Phosphorylation Sites (1)
Ubiquitination Sites (4)

Interactors 72
Interactions 93
Network
PTM Sites 6

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 6 total post translational modifications

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NP_009409

phosphoribosylaminoimidazolesuccinocarboxamide synthase

Length: 306

1
MSITKTELDG ILPLVARGKV RDIYEVDAGT LLFVATDRIS AYDVIMENSI
51
PEKGILLTKL SEFWFKFLSN DVRNHLVDIA PGKTIFDYLP AKLSEPKYKT
101
QLEDRSLLVH KHKLIPLEVI VRGYITGSAW KEYVKTGTVH GLKQPQGLKE
151
SQEFPEPIFT PSTKAEQGEH DENISPAQAA ELVGEDLSRR VAELAVKLYS
201
KCKDYAKEKG IIIADTKFEF GIDEKTNEII LVDEVLTPDS SRFWNGASYK
251
VGESQDSYDK QFLRDWLTAN KLNGVNGVKM PQDIVDRTRA KYIEAYETLT
301
GSKWSH

Location	PTM	Residue	Source(s)	Note(s)
53	Ubiquitination	K	Beltrao P (2012)	-
53	Ubiquitination	K	Iesmantavicius V (2014)	-
160	Phosphorylation	T	Albuquerque CP (2008)	-
260	Ubiquitination	K	Swaney DL (2013)	-
291	Ubiquitination	K	Beltrao P (2012)	-
			Iesmantavicius V (2014)	-
			Swaney DL (2013)	-

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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Sumoylation	K	Sung MK (2013)	eyJOT1RFUyI6WyJiaW1vbGVjdWxhciBmbHVvcmVzY2VuY2UgY29tcGxlbWVudGF0aW9uIChCaUZDKSBhc3NheTsgQ292YWxlbnQgIG1vZGlmaWNhdGlvbiJdLCJSRUxBVElPTlNISVBTIjp7IlNNVDMiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMyNTYxXC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3NtdDMuaHRtbCcgYWx0PSdTTVQzJz5TTVQzPFwvYT48XC9zcGFuPiJ9fQ==
-	Ubiquitination	K	Kolawa NJ (2013)	eyJOT1RFUyI6WyJcIlRhYmxlIFMxLCBWYWxpZCBTdWJzdHJhdGUiLCJsaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZVwiIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJJNCI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMzEyMTVcL3N1bW1hcnlcL3NhY2NoYXJvbXljZXMtY2VyZXZpc2lhZVwvdWJpNC5odG1sJyBhbHQ9J1VCSTQnPlVCSTQ8XC9hPjxcL3NwYW4+In19
			Swaney DL (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
			Ziv I (2011)	eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
SMT3	Conjugate	-	Sumoylation	K	PTM	Sung MK (2013)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Kolawa NJ (2013)
						Swaney DL (2013)
						Ziv I (2011)

Result Summary