Saccharomyces cerevisiae (S288c)

MDH1

malate dehydrogenase MDH1, L000001045, YKL085W

Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated

GO Process (4)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

aerobic respiration [IMP]

chronological cell aging [IMP]

replicative cell aging [IMP]

tricarboxylic acid cycle [IMP]

Gene Ontology Molecular Function

L-malate dehydrogenase activity [IDA, IMP]
mRNA binding [IDA]

Gene Ontology Cellular Component

mitochondrial matrix [IDA]

mitochondrion [IDA, IMP, IPI]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

34048

559292

PTM statistics

Proteins

PTM Sites

Publications

Phosphorylation Sites (3)
Ubiquitination Sites (2)

Interactors 173
Interactions 218
Network
PTM Sites 5

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 5 total post translational modifications

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NP_012838

malate dehydrogenase MDH1

Length: 334

1
MLSRVAKRAF SSTVANPYKV TVLGAGGGIG QPLSLLLKLN HKVTDLRLYD
51
LKGAKGVATD LSHIPTNSVV KGFTPEEPDG LNNALKDTDM VLIPAGVPRK
101
PGMTRDDLFA INASIVRDLA AATAESAPNA AILVISNPVN STVPIVAQVL
151
KNKGVYNPKK LFGVTTLDSI RAARFISEVE NTDPTQERVN VIGGHSGITI
201
IPLISQTNHK LMSDDKRHEL IHRIQFGGDE VVKAKNGAGS ATLSMAHAGA
251
KFANAVLSGF KGERDVIEPS FVDSPLFKSE GIEFFASPVT LGPDGIEKIH
301
PIGELSSEEE EMLQKCKETL KKNIEKGVNF VASK

Location	PTM	Residue	Source(s)	Note(s)
177	Phosphorylation	S	Reinders J (2007)	-
196	Phosphorylation	S	Holt LJ (2009)	-
199	Phosphorylation	T	Holt LJ (2009)	-
278	Ubiquitination	K	Starita LM (2011)	-

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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Ubiquitination	K	Braun B (2011)	eyJOT1RFUyI6WyJsaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZSJdLCJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
-	Ubiquitination	K	Starita LM (2011)	eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZXMiLCJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iXSwiUkVMQVRJT05TSElQUyI6eyJVQkk0IjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8zMTIxNVwvc3VtbWFyeVwvc2FjY2hhcm9teWNlcy1jZXJldmlzaWFlXC91Ymk0Lmh0bWwnIGFsdD0nVUJJNCc+VUJJNDxcL2E+PFwvc3Bhbj4ifX0=

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Braun B (2011)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Starita LM (2011)

Result Summary