Saccharomyces cerevisiae (S288c)

GUA1

GMP synthase (glutamine-hydrolyzing), L000000744, YMR217W
GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA
Download Curated Data for this Protein
35395
559292
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  • Interactors 53
  • Interactions 57
  • Network
  • PTM Sites 6
Sites with Multi-PTMs
Displaying 1 protein 1 non-assigned with 6 total post translational modifications
2
3
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NP_013944

GMP synthase (glutamine-hydrolyzing)
Length: 525
1
MAAGEQVSNM FDTILVLDFG SQYSHLITRR LREFNIYAEM LPCTQKISEL
51
GWTPKGVILS GGPYSVYAED APHVDHAIFD LNVPILGICY GMQELAWING
101
KQVGRGDKRE YGPATLKVID DSNSLFKGMN DSTVWMSHGD KLHGLPTGYK
151
TIATSDNSPY CGIVHETKPI YGIQFHPEVT HSTQGKTLLK NFAVDLCHAK
201
QNWTMENFID TEINRIRKLV GPTAEVIGAV SGGVDSTVAS KLMTEAIGDR
251
FHAILVDNGV LRLNEAANVK KTLVEGLGIN LMVVDASEEF LSKLKGVTDP
301
EKKRKIIGNT FIHVFEREAE KIKPKDGKEI QFLLQGTLYP DVIESISFKG
351
PSQTIKTHHN VGGLLENMKL KLIEPLRELF KDEVRHLGEL LGIPHDLVWR
401
HPFPGPGIAI RVLGEVTKEQ VEIARKADNI YIEEIKKAGL YNQISQAFAC
451
LLPVKSVGVM GDQRTYDQVI ALRAIETTDF MTADWFPFEH SFLKKVASRI
501
VNEVDGVARV TYDITSKPPA TVEWE
LocationPTMResidueSource(s)Note(s)
122PhosphorylationS
eyJOT1RFUyI6WyJQTUlEIDIxMTI2MzM2OiBQcmVkaWN0ZWQgcHJvdGVpbiBraW5hc2UgPSBDS0EyIl19
124PhosphorylationS
-
241UbiquitinationK
-
-
426UbiquitinationK
-
517UbiquitinationK
-
1
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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.
LocationPTMResidueSource(s)Note(s)
-UbiquitinationK
eyJOT1RFUyI6WyJcIlRhYmxlIFMxLCBWYWxpZCBTdWJzdHJhdGUiLCJsaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZVwiIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJJNCI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMzEyMTVcL3N1bW1hcnlcL3NhY2NoYXJvbXljZXMtY2VyZXZpc2lhZVwvdWJpNC5odG1sJyBhbHQ9J1VCSTQnPlVCSTQ8XC9hPjxcL3NwYW4+In19
eyJOT1RFUyI6WyJMaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZXMiLCJDYW5kaWRhdGUgdWJpcXVpdGluIHN1YnN0cmF0ZXMgd2VyZSBpZGVudGlmaWVkIHVzaW5nIHViaXF1aXRpbiByZW1uYW50IGltbXVub2FmZmluaXR5IHByb2ZpbGluZy4iXSwiUkVMQVRJT05TSElQUyI6eyJVQkk0IjoiPHNwYW4+PGEgaHJlZj0naHR0cHM6XC9cL3RoZWJpb2dyaWQub3JnXC8zMTIxNVwvc3VtbWFyeVwvc2FjY2hhcm9teWNlcy1jZXJldmlzaWFlXC91Ymk0Lmh0bWwnIGFsdD0nVUJJNCc+VUJJNDxcL2E+PFwvc3Bhbj4ifX0=
eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

ProteinRelationshipLocationPTMResidueIdentitySource(s)
UBI4Conjugate-UbiquitinationKPTM