Saccharomyces cerevisiae (S288c)

NOP4

NOP77, L000001262, L000001263, YPL043W

Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)

GO Process (2)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [IMP]

ribosomal large subunit biogenesis [IMP]

Gene Ontology Molecular Function

RNA binding [ISS]
mRNA binding [IDA]

Gene Ontology Cellular Component

nucleolus [IDA]

nucleus [IDA]

preribosome, large subunit precursor [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

36136

559292

PTM statistics

Proteins

PTM Sites

Publications

Phosphorylation Sites (6)
Ubiquitination Sites (9)

Interactors 235
Interactions 431
Network
PTM Sites 15

Sites with Multi-PTMs

Displaying 1 protein 1 non-assigned with 15 total post translational modifications

Sort By: [Default] [Alphabetical] [PTM count] [Length] [Status]

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NP_015282

Nop4p

Length: 685

1
MEETIENVEV PSSNVSKQND DGLDMKTLFV RSIPQDVTDE QLADFFSNFA
51
PIKHAVVVKD TNKRSRGFGF VSFAVEDDTK EALAKARKTK FNGHILRVDI
101
AKRRDRSKKT SEVVEKSTPE SSEKITGQNN EDEDDADGED SMLKGKPKLI
151
IRNMPWSCRD PVKLKKIFGR YGTVVEATIP RKRDGKLCGF AFVTMKKISN
201
CRIALENTKD LKIDGRKVAV DFAVQKNRWE DYKKAQPEMN DKDDNESGNE
251
DAEENHDDEE DENEEEDRQV DQASKNKESK RKAQNKREDF SVFVRNVPYD
301
ATEESLAPHF SKFGSVKYAL PVIDKSTGLA KGTAFVAFKD QYTYNECIKN
351
APAAGSTSLL IGDDVMPEYV YEGRVLSITP TLVREDAGRM AEKNAAKRKE
401
ALGKAPGEKD RRNLYLLNEG RVVEGSKMAD LLTNTDMEIR EKSYKLRVEQ
451
LKKNPSLHLS MTRLAIRNLP RAMNDKALKA LARKAVVEFA TEVKNKERHP
501
LSKEEIIRST KEKYKFMGPD EIEAQKKKDK KSGVVKQAKV IMEVKGSTAG
551
RSRGYGFVEF RDHKNALMGL RWLNCHAVTS DEILEGLNDD EKKQVDNDLG
601
KGRRLCVEFA IENSNVVKRR REQLKQARTK RTRPDNEDTG DVGESENKKP
651
KKEEATTPTN PDDKKMGDDI KRIIGFKRKR KHAKK

Location	PTM	Residue	Source(s)	Note(s)
53	Ubiquitination	K	Mayor T (2005)	-
53	Ubiquitination	K	Mayor T (2007)	-
117	Phosphorylation	S	Albuquerque CP (2008)	-
173	Phosphorylation	T	Albuquerque CP (2008)	-
217	Ubiquitination	K	Mayor T (2005)	-
226	Ubiquitination	K	Mayor T (2005)	-
247	Phosphorylation	S	Bodenmiller B (2010)	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
			Holt LJ (2009)	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
			Li X (2007)	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
			Soulard A (2010)	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
312	Ubiquitination	K	Mayor T (2005)	-
317	Ubiquitination	K	Mayor T (2005)	-
325	Ubiquitination	K	Iesmantavicius V (2014)	-
			Mayor T (2005)	-
			Swaney DL (2013)	-
349	Ubiquitination	K	Mayor T (2007)	-
377	Phosphorylation	S	Holt LJ (2009)	-
379	Phosphorylation	T	Gruhler A (2005)	eyJOT1RFUyI6WyI3LjcgUmVjaXByb2NhbCBTSUxBQyByYXRpbyBwaGVyb21vbmUgdHJlYXRlZDp1bnRyZWF0ZWQgUE1JRDoxNTY2NTM3NyJdfQ==
444	Phosphorylation	Y	Helbig AO (2010)	-
564	Ubiquitination	K	Mayor T (2007)	-

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
PTK1	Kinase	247	Phosphorylation	S	catalytic	Bodenmiller B (2010)

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Non-Assigned PTMs

Post translational modifications that are currently unassigned to a specific residue location.

Location	PTM	Residue	Source(s)	Note(s)
-	Ubiquitination	K	Mayor T (2005)	eyJOT1RFUyI6WyJIaXMtdGFnZ2VkIHViaXF1aXRpbiAoVWJpNHApIHdhcyB1c2VkIHRvIGlkZW50aWZ5IHViaXF1aXR5bGF0ZWQgcHJvdGVpbnMuIl0sIlJFTEFUSU9OU0hJUFMiOnsiVUJJNCI6IjxzcGFuPjxhIGhyZWY9J2h0dHBzOlwvXC90aGViaW9ncmlkLm9yZ1wvMzEyMTVcL3N1bW1hcnlcL3NhY2NoYXJvbXljZXMtY2VyZXZpc2lhZVwvdWJpNC5odG1sJyBhbHQ9J1VCSTQnPlVCSTQ8XC9hPjxcL3NwYW4+In19
			Mayor T (2007)	eyJOT1RFUyI6WyJsaWtlbHkgdWJpcXVpdGluIGNvbmp1Z2F0ZSJdLCJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==
			Swaney DL (2013)	eyJSRUxBVElPTlNISVBTIjp7IlVCSTQiOiI8c3Bhbj48YSBocmVmPSdodHRwczpcL1wvdGhlYmlvZ3JpZC5vcmdcLzMxMjE1XC9zdW1tYXJ5XC9zYWNjaGFyb215Y2VzLWNlcmV2aXNpYWVcL3ViaTQuaHRtbCcgYWx0PSdVQkk0Jz5VQkk0PFwvYT48XC9zcGFuPiJ9fQ==

Relationships

Protein	Relationship	Location	PTM	Residue	Identity	Source(s)
UBI4	Conjugate	-	Ubiquitination	K	PTM	Mayor T (2005)
						Mayor T (2007)
						Swaney DL (2013)

Result Summary

NOP4

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA binding [ISS]mRNA binding [IDA]

Gene Ontology Cellular Component

NP_015282

Relationships

Non-Assigned PTMs

Relationships

RNA binding [ISS]
mRNA binding [IDA]