Welcome to PhosphoGRID

PhosphoGRID is an online database of experimentally verified in vivo protein phosphorylation sites in the model eukaryotic organism Saccharomyces cerevisisae. The database includes results from both high throughput (HTP) MS proteomics studies in addition to phosphosites identified in low throughput (LTP) studies of individual proteins or protein complexes. The identity of specific protein kinases and phosphatases shown to regulate appearance of phosphorylations are recorded, where available, as are the function(s) of the phosphorylation, and conditions under which the modification was demonstrated to occur. The PhosphoGRID curators would appreciate comments on omissions and errors, as well as notifications of newly published or submitted data.

This work was supported by:

  • Canadian Institutes of Health Research grant (MOP-77807 - to I.S.)
  • Canadian Cancer Society Research Institute Grant (0011258 to I.S.)
  • Canadian Institutes of Health Research grant (GSP-36651 to M.T.)
  • NIH National Center for Research Resources Grant (1R01RR024031-01 to M.T. and K.D.)


Latest News

New Dataset of 326,790 Saccharomyces cerevisiae Genetic Interactions

December 7, 2016 - 6:03 am

The BioGRID has loaded a new comprehensive SGA dataset of 326,790 high confidence genetic interactions in the budding yeast Saccharomyces cerevisae as reported by Costanzo et al in the publication: "A global genetic interaction network maps a wiring diagram of cellular function." (Science 2016) [Science][BioGRID][Pubmed]. The dataset and associated quantitative scores are available immediately online via all standard BioGRID searches and supported download formats.

A special thanks to the contributors Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, Lin ZY, Kuzmin E, Nelson J, Piotrowski JS, Srikumar T, Bahr S, Chen Y, Deshpande R, Kurat CF, Li SC, Li Z, Usaj MM, Okada H, Pascoe N, San Luis BJ, Sharifpoor S, Shuteriqi E, Simpkins SW, Snider J, Suresh HG, Tan Y, Zhu H, Malod-Dognin N, Janjic V, Przulj N, Troyanskaya OG, Stagljar I, Xia T, Ohya Y, Gingras AC, Raught B, Boutros M, Steinmetz LM, Moore CL, Rosebrock AP, Caudy AA, Myers CL, Andrews B and Boone C.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

BioGRID Version 3.4.143 Released

December 7, 2016 - 5:48 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 57,763 publications. These additions bring our total number of non-redundant interactions to 1,104,640, raw interactions to 1,410,457, non-redundant chemical associations to 11,805, raw chemical associations to 27,745, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.142 Released

November 1, 2016 - 4:19 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 57,513 publications. These additions bring our total number of non-redundant interactions to 842,529, raw interactions to 1,079,789, non-redundant chemical associations to 11,805, raw chemical associations to 27,745, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.141 Released

October 1, 2016 - 3:22 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 57,184 publications. These additions bring our total number of non-redundant interactions to 836,880, raw interactions to 1,073,218, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.140 Released

September 1, 2016 - 2:47 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 57,058 publications. These additions bring our total number of non-redundant interactions to 836,212, raw interactions to 1,072,173, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.139 Released

August 1, 2016 - 4:37 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 56,908 publications. These additions bring our total number of non-redundant interactions to 834,331, raw interactions to 1,069,563, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.138 Released

July 1, 2016 - 1:13 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 56,795 publications. These additions bring our total number of non-redundant interactions to 833,833, raw interactions to 1,068,567, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.137 Released

June 1, 2016 - 5:18 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 56,683 publications. These additions bring our total number of non-redundant interactions to 832,938, raw interactions to 1,067,443, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.136 Released

May 1, 2016 - 2:25 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 56,621 publications. These additions bring our total number of non-redundant interactions to 832,222, raw interactions to 1,066,335, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.135 Released

April 1, 2016 - 4:25 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 56,600 publications. These additions bring our total number of non-redundant interactions to 827,858, raw interactions to 1,060,041, non-redundant chemical associations to 11,694, raw chemical associations to 27,501, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

National Institutes of HealthBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchThe University of EdinburghPrinceton UniversitySamuel Lunenfeld Research InstituteSaccharomyces Genome DatabaseFlybaseGeneDBNational Center for Biotechnology InformationHuman Protein Reference DatabaseWormbaseGene OntologyThe International Molecular Exchange ConsortiumDatabase of Interacting ProteinsIntACTMolecular Interaction DatabaseProteomics Standards InitiativeReactomeCytoscapeOsprey Network Visualization SystemPathway Commons