Welcome to PhosphoGRID

PhosphoGRID is an online database of experimentally verified in vivo protein phosphorylation sites in the model eukaryotic organism Saccharomyces cerevisisae. The database includes results from both high throughput (HTP) MS proteomics studies in addition to phosphosites identified in low throughput (LTP) studies of individual proteins or protein complexes. The identity of specific protein kinases and phosphatases shown to regulate appearance of phosphorylations are recorded, where available, as are the function(s) of the phosphorylation, and conditions under which the modification was demonstrated to occur. The PhosphoGRID curators would appreciate comments on omissions and errors, as well as notifications of newly published or submitted data.

This work was supported by:

  • Canadian Institutes of Health Research grant (MOP-77807 - to I.S.)
  • Canadian Cancer Society Research Institute Grant (0011258 to I.S.)
  • Canadian Institutes of Health Research grant (GSP-36651 to M.T.)
  • NIH National Center for Research Resources Grant (1R01RR024031-01 to M.T. and K.D.)


NOTICE OF REDIRECTION

PhosphoGRID search results have been permanently re-directed into the BioGRID website as our scope has expanded to cover additional post translational modifications and additional model organisms. These and ALL future efforts of our ongoing curation of post translational modifications are available online now at the BioGRID Website.



Latest News

BioGRID Version 3.4.154 Released

November 1, 2017 - 4:44 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 63,848 publications. These additions bring our total number of non-redundant interactions to 1,167,125, raw interactions to 1,505,899, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.153 Released

October 1, 2017 - 3:21 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 63,683 publications. These additions bring our total number of non-redundant interactions to 1,162,605, raw interactions to 1,499,723, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.152 Released

September 1, 2017 - 4:03 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 63,487 publications. These additions bring our total number of non-redundant interactions to 1,158,978, raw interactions to 1,495,320, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.151 Released

August 1, 2017 - 3:27 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 63,354 publications. These additions bring our total number of non-redundant interactions to 1,158,266, raw interactions to 1,493,749, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

Comprehensive Update to Fruit Fly Dataset from FlyBase includes 19,000+ New Interactions

July 10, 2017 - 5:14 pm

BioGRID update 3.4.150 includes a comprehensive update to our Drosophila melanogaster (Fruit Fly) dataset in partnership with FlyBase.org. This update verifies and validates more than 48,000 existing interactions and incorporates an additional 19,000+ new interactions across more than 6,100 total publications. This update also increases the total number of Drosophila melanogaster interactions deposited in BioGRID to 67,932. These interactions and all associated meta data are available immediately online via all standard BioGRID searches and supported download formats. You can also find them available at FlyBase.org in all search result pages and in FlyBase.org download files.

A special thanks to the entire FlyBase Consortium for their tireless curation efforts and in particular Gil dos Santos for directly helping facilitate the BioGRID collaboration.

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

BioGRID Version 3.4.150 Released

July 1, 2017 - 5:56 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 63,281 publications. These additions bring our total number of non-redundant interactions to 1,153,781, raw interactions to 1,488,522, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

New Dataset of 56,473 Human Affinity Capture-MS Interactions

June 6, 2017 - 9:03 pm

The BioGRID has loaded a new comprehensive Affinity Capture-MS dataset of 56,473 high confidence protein interactions in Human as reported by Huttlin EL et al in the publication: "Architecture of the human interactome defines protein communities and disease networks." (Nature 2017) [Nature][BioGRID][Pubmed]. The dataset and associated modified CompPASS scores are available immediately online via all standard BioGRID searches and supported download formats.

A special thanks to the contributors Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, and Harper JW

If you have an interaction dataset you'd like to deposit directly into the BioGRID, please contact us at biogridadmin@gmail.com.

BioGRID Version 3.4.149 Released

June 1, 2017 - 2:38 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 58,897 publications. These additions bring our total number of non-redundant interactions to 1,137,230, raw interactions to 1,467,186, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.148 Released

May 1, 2017 - 4:19 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 58,777 publications. These additions bring our total number of non-redundant interactions to 1,112,963, raw interactions to 1,423,105, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

BioGRID Version 3.4.147 Released

April 1, 2017 - 2:55 am

The BioGRID's curated set of physical and genetic interactions has been updated to include interactions, chemical associations, and post-translational modifications (PTM) from 58,514 publications. These additions bring our total number of non-redundant interactions to 1,111,552, raw interactions to 1,421,025, non-redundant chemical associations to 11,820, raw chemical associations to 27,785, Unique PTM Sites to 19,981, and Un-Assigned PTMs to 18,578. New curated data will be added in curation updates on a monthly basis. For a more comprehensive breakdown of our numbers, check out our latest interaction statistics. To download these data, visit our download page.

National Institutes of HealthBiotechnology and Biological Sciences Research CouncilCanadian Institutes of Health ResearchThe University of EdinburghPrinceton UniversitySamuel Lunenfeld Research InstituteSaccharomyces Genome DatabaseFlybaseGeneDBNational Center for Biotechnology InformationHuman Protein Reference DatabaseWormbaseGene OntologyThe International Molecular Exchange ConsortiumDatabase of Interacting ProteinsIntACTMolecular Interaction DatabaseProteomics Standards InitiativeReactomeCytoscapeOsprey Network Visualization SystemPathway Commons