Saccharomyces cerevisiae (S288c)

MED8

L000003917, YBR193C

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

GO Process (2)

GO Function (4)

GO Component (1)

Gene Ontology Biological Process

negative regulation of transcription from RNA polymerase II promoter [IDA]

positive regulation of transcription from RNA polymerase II promoter [IMP]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II transcription corepressor activity [IPI]
TBP-class protein binding [IDA]
structural molecule activity [IMP]

Gene Ontology Cellular Component

core mediator complex [IDA]

SGD Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Download Curated Data for this Protein

32890

559292

Interactors 627
Interactions 945
Network

Result Summary

MED8

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]RNA polymerase II transcription corepressor activity [IPI]TBP-class protein binding [IDA]structural molecule activity [IMP]

Gene Ontology Cellular Component

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II transcription corepressor activity [IPI]
TBP-class protein binding [IDA]
structural molecule activity [IMP]